Clinical Trials
The Tumor Immunotherapy Program has a number of studies that are currently recruiting patients. For information about how to be referred to one of these studies, please contact us.
Closed Recruiting
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INSPIRE
INvestigator-initiated Phase II Study of pembrolizumab immunological response evaluation
Sponsor: In-House
Principal Investigator: Dr. Lillian Siu
NCT#: NCT02644369
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ACTIVATE
Phase Ib trial of pembrolizumab administered in combination or following adoptive cell therapy: A multiple cohort study
Sponsor: In-House
Principal Investigator: Dr. Marcus Butler
NCT#: NCT02811497
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METADUR
An open-label, phase II basket study of a hypomethylating agent azacitidine and durvalumab (anti-PDL1) in advanced solid tumors.
Sponsor: In-House
Principal Investigator: Dr. Lillian Siu
NCT#: NCT02811497
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PRIMED
Window of opportunity study for patients with resectable squamous cell carcinoma of the oral cavity who are considered suitable for curative-intent surgical resection, with pre-operative mocetinostat and durvalumab. Eligible Tumour Type(s): squamous cell carcinoma of the oral cavity
Sponsor: In-House
Principal Investigator: Dr. Lillian Siu
NCT#: NCT02993991 -
Role of microbiome as a biomarker in loco-regionally-advanced oropharyngeal squamous cell carcinoma (ROMA)Eligible Tumour Type(s): Squamous Cell Carcinoma of the Oral Cavity
Sponsor: In-house
Principal Investigator: Drs. Lillian Siu and Anna Spreafic
NCT#: N/A -
Sitravatinib (MGCD516) and Nivolumab in Oral cavity cancer Window opportunity study (SNOW)Eligible Tumour Type(s): Squamous Cell Carcinoma of the Oral Cavity
Sponsor: In-house
Principal Investigator: Dr. Lillian Siu
NCT#: NCT03575598 -
Tumor Immunotherapy and MicrobiomE Analysis Project (TIME)Eligible Tumour Type(s): Metastatic Melanoma
Sponsor: In-house
Principal Investigator: Dr. Marcus Butler
NCT#: N/A -
Role of Microbiome as a Biomarker in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma 2 (ROMA LA-OPSCC-2)Eligible Tumour Type(s): Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma
Sponsor: In-house
Principal Investigator: Dr. Anna Spreafico
NCT#: NCT03838601
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