Centre for Integrative Immune Analysis

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Our Mission

To enable in-depth immunological analysis for translational and clinical studies.

Our Expertise

Advanced immunological assays and bioinformatics pipelines.

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Our Clients

  • UHN Investigators
  • External Academic Investigators
  • Multi-Institute Networks
  • Industry

Overview

Specimen Processing

Blood

NaHep | EDTA | Streck | SST

whole blood, buffy coat, PBMCs, plasma, serum

Tissues

Core & Punch Biopsies | Surgical excisions

FFPE, OCT, snap-frozen, single-cells

Fluids

Fluids (ascites, pleural effusions, paracentesis

single-cells, supernatant

*Stool

*kits & storage only

*Saliva

*kits & storage only

Short & Long-term Storage

Short-term: -80°C Long-term: -196°C

Assays & Protocols

A photo of Flow Cytometry

Flow Cytometry

(Traditional & Spectral Flow)

T/B/NK, T/Treg, myeloid subsets

A photo of CyTOF

CyTOF

(40+ marker panels)

immune phenotyping including checkpoint/activation markers

A photo of Cytokines

Cytokines

(1 to 80-plex)

cytokines, chemokines, growth factors

A photo of Cell Sorting

Cell Sorting

(Up to 6 populations)

PBMCs, tumor-infiltrating lymphocytes for scRNA-seq

A photo of Genomics

Genomics

PMGC & OICR-TGL

sample preparation and data analysis: scRNA-seq, CITE-seq, TCR-seq

A photo of IHC

IHC

(Traditional & Multiplex)

1 to 6 markers on a single slide (FFPE)

A photo of Specificity Assays

Specificity Assays

ELISpot, re-stimulation

IFN-ɣ production, multimer staining

A photo of Metabolomics

Metabolomics

HPLC, mass-spec (NRC)

IDO activity, immuno-metabolomic profiling

A photo of TILs

TILs

Expansion in IL-2

TIL profiling

Our Team

A group photo of the immune monitoring team

Executive Team

A photo of Ben Wang

Ben Wang

Head, Centre for Integrative Immune Analysis

A photo of Marcus Butler

Marcus Butler

Clinical Head, Centre for Integrative Immune Analysis

A photo of Pam Ohashi

Pam Ohashi

Director, TIP Senior Scientist

A photo of Naoto Hirano

Naoto Hirano

Immuno-Oncology Chair, PM Senior Scientist

A photo of Trevor Pugh

Trevor Pugh

Director of Genomics, OICR Senior Scientist

A photo of David Brooks

David Brooks

Senior Scientist

A photo of Tracy McGaha

Tracy McGaha

Senior Scientist

A photo of Linh Nguyen

Linh Nguyen

Head, Centre for Cell Manufacturing

A photo of Hal Berman

Hal Berman

Pathologist

A photo of Adam Gehring

Adam Gehring

Senior Scientist

Connect

How to Connect

When to Connect

  • Anytime for consultation

  • During protocol development or prior to an amendment

  • Preparing a grant submission

  • Specimens ready for analysis (e.g. PBMCs, FFPE tissues, etc.)

  • Datasets ready for analysis (e.g. scRNA-seq, CITE-seq, etc.)

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