Clinical Trials

The Tumor Immunotherapy Program has a number of studies that are currently recruiting patients. For information about how to be referred to one of these studies, please contact us.

Currently Recruiting

  • TCR2-18-01

    A Phase 1/2 Single Arm Open-Label Clinical Trial of Tc-210 T Cells In Patients with Advanced Mesothelin-Expressing Cancer

    Eligible Tumour Type(s): Solid Cancer
    Principal Investigator: Dr. Marcus Butler
    NCT#: NCT03907852

    https://clinicaltrials.gov/ct2/show/NCT03907852

  • IOV-LUN-202

    A Phase 2 Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients with Metastatic Non-Small-Cell Lung Cancer 

    Eligible Tumour Type(s): Non-small Cell Lung Cancer
    Principal Investigator: Dr. Adrian Sacher
    NCT#: NCT04614103

    https://clinicaltrials.gov/ct2/show/NCT04614103

  • TAC01-HER2-03

    A Phase I/II Trial Investigating Safety and Efficacy of Autologous TAC T Cells Targeting HER2 in Relapsed or Refractory Solid Tumors (TACTIC-2) 

    Eligible Tumour Type(s): Solid Cancer
    Principal Investigator: Dr. Adrian Sacher
    NCT#: NCT04727151

    https://clinicaltrials.gov/ct2/show/NCT04727151

  • Phase I Study of Autologous Acute Myelogenous Leukemia (AML) Cells Containing Lentivirus Engineering

    This is a phase 1 study (the first stage in testing a new treatment to see how safe and tolerable the treatment is) which will include patients with acute myeloid leukemia (AML) that has either returned or has a more than a 70% chance of coming back and cannot have a bone marrow transplant.

    This study will see whether modifying a patient's AML cells to produce IL-12 and giving it back to the patient is safe and useful in patients with AML that cannot have bone marrow transplants.

    Eligible Tumour Type(s): Acute Myeloid Leukemia (AML)
    Sponsor: In-House
    Principal Investigator: Dr. Mark Minden
    NCT#: NCT02483312

    https://clinicaltrials.gov/ct2/show/NCT02483312

  • Feasibility Study of Microbial Ecosystem Therapeutics (MET-4) to Evaluate Effects of Fecal Microbiome in Patients on ImmunOtherapy (MET4-IO)
    Eligible Tumour Type(s): Breast Cancer, Colorectal Cancer, Fallopian Tube Tumours, Malignant Pleural Mesothelioma, Metastatic Melanoma, Ovarian Cancer, Solid Cancer, Squamous Cell Cancer of the Head and Neck, Squamous Cell Carcinoma of the Oral Cavity, Triple Negative Breast Cancer
    Sponsor: In-house
    Principal Investigator: Drs. Lillian Siu & Anna Spreafico (Second PI)
    NCT#: NCT03686202

    https://clinicaltrials.gov/ct2/show/NCT03686202

  • Prospective Analysis of INteStinal Microbiome and Autoimmune PanEls as PrediCtors of Toxicity in Phase I ImmunOncology Patients (INSPECT-IO)
    Eligible Tumour Type(s): Solid Cancer
    Sponsor: In-house
    Principal Investigator: Dr. Anna Spreafico
    NCT#: NCT04107311

    https://clinicaltrials.gov/ct2/show/study/NCT04107311

Closed Recruiting

  • Role of Microbiome as a Biomarker in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma 2 (ROMA LA-OPSCC-2)
    Eligible Tumour Type(s): Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma
    Sponsor: In-house
    Principal Investigator: Dr. Anna Spreafico
    NCT#: NCT03838601

    https://clinicaltrials.gov/ct2/show/NCT03838601

  • TILs-001-DC

    A Phase I Study evaluating the feasibility and safety of infusion of Re-StimulatedAutologous tumor-infiltrating lymphocytes (TILs) followed by low-dose interleukin-2 therapy in patients with platinum resistant high grade serous ovarian, fallopian tube, or primary peritoneal cancer

    Eligible Tumour Type(s): Ovarian Cancer
    Sponsor: In-House
    Principal Investigator: Dr. Marcus Butler
    NCT#: NCT01883297

    https://clinicaltrials.gov/ct2/show/NCT01883297

  • TILs-002-MEL

    Phase II Study evaluating the infusion of autologous tumor-infiltrating lymphocytes (TILs) and low-dose interleukin-2 (IL-2) therapy following a preparative regimen of non-myeloablative lymphodepletion using cyclophosphamide and fludarabine in patients with metastatic melanoma.

    Eligible Tumour Type(s): Metastatic Melanoma
    Sponsor: In-House
    Principal Investigator: Dr. Marcus Butler
    NCT#: NCT01883323

    https://clinicaltrials.gov/ct2/show/NCT01883323?term=TILs-002-MEL&rank=1

  • 1301-02

    Phase 1b Study of NY-ESO-1 specific TCR gene transduced autologous T lymphocytes in patients with solid tumors

    Eligible Tumour Type(s): Solid Cancer
    Sponsor: In-house (in collaboration with Takara Bio Inc)
    Principal Investigator: Marcus Butler
    NCT#: NCT02869217

    https://clinicaltrials.gov/ct2/show/NCT02869217

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